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13 best Python Ethereum libraries in 2025

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by naveen.kumar@openweaver.com dot icon Updated: Mar 15, 2023

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Python Ethereum Python Ethereum libraries provide a comprehensive range of tools to work with smart contracts, including the Solidity programming language. The availability of several established frameworks and efficient libraries makes it the preferred programming language for blockchain developers. Py-EVM is a Python implementation of the Ethereum Virtual Machine (EVM). It is useful for testing and debugging smart contracts before deploying them to production environments. PyEthereum The most popular library for working with the Ethereum network. It allows you to create and send transactions, as well as interact with contracts written in Solidity. Build wallets, mine coins, integrate with crypto exchanges, trading bots, and more for Ethereum with the following 13 best Python Ethereum libraries in 2022:

web3.pyby ethereum

Python doticonstar image 4289 doticonVersion:v3.11.1doticon
License: Permissive (MIT)

A python interface for interacting with the Ethereum blockchain and ecosystem.

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            web3.pyby ethereum

            Python doticon star image 4289 doticonVersion:v3.11.1doticon License: Permissive (MIT)

            A python interface for interacting with the Ethereum blockchain and ecosystem.
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                      mythrilby ConsenSys

                      Python doticonstar image 3425 doticonVersion:v0.23.23doticon
                      License: Permissive (MIT)

                      Security analysis tool for EVM bytecode. Supports smart contracts built for Ethereum, Hedera, Quorum, Vechain, Roostock, Tron and other EVM-compatible blockchains.

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                                mythrilby ConsenSys

                                Python doticon star image 3425 doticonVersion:v0.23.23doticon License: Permissive (MIT)

                                Security analysis tool for EVM bytecode. Supports smart contracts built for Ethereum, Hedera, Quorum, Vechain, Roostock, Tron and other EVM-compatible blockchains.
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                                          eth2.0-specsby ethereum

                                          Python doticonstar image 2002 doticonVersion:v1.1.0-beta.2doticon
                                          License: Permissive (CC0-1.0)

                                          Ethereum 2.0 Specifications

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                                                    eth2.0-specsby ethereum

                                                    Python doticon star image 2002 doticonVersion:v1.1.0-beta.2doticon License: Permissive (CC0-1.0)

                                                    Ethereum 2.0 Specifications
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                                                              brownieby eth-brownie

                                                              Python doticonstar image 2442 doticonVersion:v1.19.3doticon
                                                              License: Permissive (MIT)

                                                              A Python-based development and testing framework for smart contracts targeting the Ethereum Virtual Machine.

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                                                                        brownieby eth-brownie

                                                                        Python doticon star image 2442 doticonVersion:v1.19.3doticon License: Permissive (MIT)

                                                                        A Python-based development and testing framework for smart contracts targeting the Ethereum Virtual Machine.
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                                                                                  py-evmby ethereum

                                                                                  Python doticonstar image 1996 doticonVersion:v0.4.0-alpha.1doticon
                                                                                  License: Permissive (MIT)

                                                                                  A Python implementation of the Ethereum Virtual Machine

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                                                                                            py-evmby ethereum

                                                                                            Python doticon star image 1996 doticonVersion:v0.4.0-alpha.1doticon License: Permissive (MIT)

                                                                                            A Python implementation of the Ethereum Virtual Machine
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                                                                                                      smart-contractsby TokenMarketNet

                                                                                                      Python doticonstar image 1305 doticonVersion:Currentdoticon
                                                                                                      License: Others (Non-SPDX)

                                                                                                      Ethereum smart contracts for security and utility tokens

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                                                                                                                smart-contractsby TokenMarketNet

                                                                                                                Python doticon star image 1305 doticonVersion:Currentdoticon License: Others (Non-SPDX)

                                                                                                                Ethereum smart contracts for security and utility tokens
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                                                                                                                          btcrelayby ethereum

                                                                                                                          Python doticonstar image 569 doticonVersion:Currentdoticon
                                                                                                                          License: Permissive (MIT)

                                                                                                                          Ethereum contract for Bitcoin SPV: Live on https://etherscan.io/address/0x41f274c0023f83391de4e0733c609df5a124c3d4

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                                                                                                                                    btcrelayby ethereum

                                                                                                                                    Python doticon star image 569 doticonVersion:Currentdoticon License: Permissive (MIT)

                                                                                                                                    Ethereum contract for Bitcoin SPV: Live on https://etherscan.io/address/0x41f274c0023f83391de4e0733c609df5a124c3d4
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                                                                                                                                              trinityby ethereum

                                                                                                                                              Python doticonstar image 464 doticonVersion:v0.1.0-alpha.36doticon
                                                                                                                                              License: Permissive (MIT)

                                                                                                                                              The Trinity client for the Ethereum network

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                                                                                                                                                        trinityby ethereum

                                                                                                                                                        Python doticon star image 464 doticonVersion:v0.1.0-alpha.36doticon License: Permissive (MIT)

                                                                                                                                                        The Trinity client for the Ethereum network
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                                                                                                                                                                  eth-proxyby Atrides

                                                                                                                                                                  Python doticonstar image 420 doticonVersion:0.0.5doticon
                                                                                                                                                                  License: Others (Non-SPDX)

                                                                                                                                                                  Stratum proxy for Ethereum

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                                                                                                                                                                            eth-proxyby Atrides

                                                                                                                                                                            Python doticon star image 420 doticonVersion:0.0.5doticon License: Others (Non-SPDX)

                                                                                                                                                                            Stratum proxy for Ethereum
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                                                                                                                                                                                      hydrachainby HydraChain

                                                                                                                                                                                      Python doticonstar image 356 doticonVersion:Currentdoticon
                                                                                                                                                                                      License: Permissive (MIT)

                                                                                                                                                                                      Permissioned Distributed Ledger based on Ethereum

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                                                                                                                                                                                                hydrachainby HydraChain

                                                                                                                                                                                                Python doticon star image 356 doticonVersion:Currentdoticon License: Permissive (MIT)

                                                                                                                                                                                                Permissioned Distributed Ledger based on Ethereum
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                                                                                                                                                                                                          MAIANby ivicanikolicsg

                                                                                                                                                                                                          Python doticonstar image 504 doticonVersion:Currentdoticon
                                                                                                                                                                                                          License: Permissive (MIT)

                                                                                                                                                                                                          MAIAN: automatic tool for finding trace vulnerabilities in Ethereum smart contracts

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                                                                                                                                                                                                                    MAIANby ivicanikolicsg

                                                                                                                                                                                                                    Python doticon star image 504 doticonVersion:Currentdoticon License: Permissive (MIT)

                                                                                                                                                                                                                    MAIAN: automatic tool for finding trace vulnerabilities in Ethereum smart contracts
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                                                                                                                                                                                                                              eth-utilsby ethereum

                                                                                                                                                                                                                              Python doticonstar image 271 doticonVersion:Currentdoticon
                                                                                                                                                                                                                              License: Permissive (MIT)

                                                                                                                                                                                                                              Utility functions for working with ethereum related codebases.

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                                                                                                                                                                                                                                        eth-utilsby ethereum

                                                                                                                                                                                                                                        Python doticon star image 271 doticonVersion:Currentdoticon License: Permissive (MIT)

                                                                                                                                                                                                                                        Utility functions for working with ethereum related codebases.
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                                                                                                                                                                                                                                                  ida-evmby crytic

                                                                                                                                                                                                                                                  Python doticonstar image 191 doticonVersion:Currentdoticon
                                                                                                                                                                                                                                                  License: Permissive (Apache-2.0)

                                                                                                                                                                                                                                                  IDA Processor Module for the Ethereum Virtual Machine (EVM)

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                                                                                                                                                                                                                                                            ida-evmby crytic

                                                                                                                                                                                                                                                            Python doticon star image 191 doticonVersion:Currentdoticon License: Permissive (Apache-2.0)

                                                                                                                                                                                                                                                            IDA Processor Module for the Ethereum Virtual Machine (EVM)
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