block-ciphers | Implementations of some lightweight block ciphers in C | Cryptography library

I'm reading up on the ProtectedMemory class in C# (which uses the Data Protection API in Windows (DPAPI)) and I see that in order to use the Protect() Method of the class, the data to be encrypted must be stored in a byte array whose size/length is a multiple of 16.

I know how to convert many different data types to byte array form and back again, but how can I guarantee that the size of a byte array is a multiple of 16? Do I literally need to create an array whose size is a multiple of 16 and keep track of the original data's length using another variable or am I missing something? With traditional block-ciphers all of these details are handled for you automatically with padding settings. Likewise, when I attempt to convert data back to its original form from a byte array, how do I ensure that any additional bytes are ignored, assuming of course that the original data wasn't a multiple of 16.

In the code sample provided in the .NET Framework documentation, the byte array utilised just so happens to be 16 bytes long so I'm not sure what best practice is in relation to this hence the question.