5 best C++ Genomics libraries in 2025

C++ is an object-oriented programming language that is fast, efficient, and powerful. C++ is one of the most popular languages for implementing and distributing bioinformatics software. Genomics is the study of genes and their functions. It includes the sequencing and analysis of genomes, which are complete sets of DNA within a single cell of an organism. In the field of genomics, with the proliferation of next-generation sequencing (NGS), the amount of DNA sequence data generated has increased exponentially. This has led to the development of new tools and algorithms to handle these enormous levels of data. Several open source libraries have been created that allow developers to quickly and easily build genomic analysis tools without having to start from scratch. There are several popular C++ Genomics open source libraries available for developers: nucleus - Python and C code for reading and writing genomics data; abyss - Assemble large genomes using short reads; vcftools - A set of tools written in Perl and C for working with VCF files, such as those generated by the 1000 Genomes Project.