multi_mut | safely getting multiple mutable references | Runtime Evironment library

I have a function that I'm applying to different sets of coordinates to create four new columns in my tibble. This function has a pretty long start-up time (loads the genome into RAM, converts tibble to GRanges, and retrieves sequences) but is relatively fast, so that there's not much difference between 100 and 1,000,000 sequences. Is there any way to send each col in the mutate to a different core so they can be processed at the same time? I thought about using pivot_long and then group+partition but this got me thinking about whether there was a different way to accomplish this. A multi_mutate of sorts?
(I don't actually expect the multiplyr partition/collect to be that time-saving in my case given the small cost to additional coordinates, but if I could avoid the time cost of pivoting, which is still relatively small, and mess in my code, that'd be cool.)