Alzhimers-Disease-Prediction-Using-Deep-learning | Convolutional Neural Networks for Alzheimer 's Disease | Machine Learning library

 by   himanshub1007 Python Version: Current License: No License

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kandi X-RAY | Alzhimers-Disease-Prediction-Using-Deep-learning Summary

Alzhimers-Disease-Prediction-Using-Deep-learning is a Python library typically used in Institutions, Learning, Education, Artificial Intelligence, Machine Learning, Deep Learning, Pytorch, Tensorflow applications. Alzhimers-Disease-Prediction-Using-Deep-learning has no bugs, it has no vulnerabilities and it has low support. However Alzhimers-Disease-Prediction-Using-Deep-learning build file is not available. You can download it from GitHub.

# AD-Prediction Convolutional Neural Networks for Alzheimer's Disease Prediction Using Brain MRI Image ## Abstract Alzheimers disease (AD) is characterized by severe memory loss and cognitive impairment. It associates with significant brain structure changes, which can be measured by magnetic resonance imaging (MRI) scan. The observable preclinical structure changes provides an opportunity for AD early detection using image classification tools, like convolutional neural network (CNN). However, currently most AD related studies were limited by sample size. Finding an efficient way to train image classifier on limited data is critical. In our project, we explored different transfer-learning methods based on CNN for AD prediction brain structure MRI image. We find that both pretrained 2D AlexNet with 2D-representation method and simple neural network with pretrained 3D autoencoder improved the prediction performance comparing to a deep CNN trained from scratch. The pretrained 2D AlexNet performed even better (**86%**) than the 3D CNN with autoencoder (**77%**). ## Method #### 1. Data In this project, we used public brain MRI data from **Alzheimers Disease Neuroimaging Initiative (ADNI)** Study. ADNI is an ongoing, multicenter cohort study, started from 2004. It focuses on understanding the diagnostic and predictive value of Alzheimers disease specific biomarkers. The ADNI study has three phases: ADNI1, ADNI-GO, and ADNI2. Both ADNI1 and ADNI2 recruited new AD patients and normal control as research participants. Our data included a total of 686 structure MRI scans from both ADNI1 and ADNI2 phases, with 310 AD cases and 376 normal controls. We randomly derived the total sample into training dataset (n = 519), validation dataset (n = 100), and testing dataset (n = 67). #### 2. Image preprocessing Image preprocessing were conducted using Statistical Parametric Mapping (SPM) software, version 12. The original MRI scans were first skull-stripped and segmented using segmentation algorithm based on 6-tissue probability mapping and then normalized to the International Consortium for Brain Mapping template of European brains using affine registration. Other configuration includes: bias, noise, and global intensity normalization. The standard preprocessing process output 3D image files with an uniform size of 121x145x121. Skull-stripping and normalization ensured the comparability between images by transforming the original brain image into a standard image space, so that same brain substructures can be aligned at same image coordinates for different participants. Diluted or enhanced intensity was used to compensate the structure changes. the In our project, we used both whole brain (including both grey matter and white matter) and grey matter only. #### 3. AlexNet and Transfer Learning Convolutional Neural Networks (CNN) are very similar to ordinary Neural Networks. A CNN consists of an input and an output layer, as well as multiple hidden layers. The hidden layers are either convolutional, pooling or fully connected. ConvNet architectures make the explicit assumption that the inputs are images, which allows us to encode certain properties into the architecture. These then make the forward function more efficient to implement and vastly reduce the amount of parameters in the network. #### 3.1. AlexNet The net contains eight layers with weights; the first five are convolutional and the remaining three are fully connected. The overall architecture is shown in Figure 1. The output of the last fully-connected layer is fed to a 1000-way softmax which produces a distribution over the 1000 class labels. AlexNet maximizes the multinomial logistic regression objective, which is equivalent to maximizing the average across training cases of the log-probability of the correct label under the prediction distribution. The kernels of the second, fourth, and fifth convolutional layers are connected only to those kernel maps in the previous layer which reside on the same GPU (as shown in Figure1). The kernels of the third convolutional layer are connected to all kernel maps in the second layer. The neurons in the fully connected layers are connected to all neurons in the previous layer. Response-normalization layers follow the first and second convolutional layers. Max-pooling layers follow both response-normalization layers as well as the fifth convolutional layer. The ReLU non-linearity is applied to the output of every convolutional and fully-connected layer. ![] images/f1.png) The first convolutional layer filters the 224x224x3 input image with 96 kernels of size 11x11x3 with a stride of 4 pixels (this is the distance between the receptive field centers of neighboring neurons in a kernel map). The second convolutional layer takes as input the (response-normalized and pooled) output of the first convolutional layer and filters it with 256 kernels of size 5x5x48. The third, fourth, and fifth convolutional layers are connected to one another without any intervening pooling or normalization layers. The third convolutional layer has 384 kernels of size 3x3x256 connected to the (normalized, pooled) outputs of the second convolutional layer. The fourth convolutional layer has 384 kernels of size 3x3x192 , and the fifth convolutional layer has 256 kernels of size 3x3x192. The fully-connected layers have 4096 neurons each. #### 3.2. Transfer Learning Training an entire Convolutional Network from scratch (with random initialization) is impractical[14] because it is relatively rare to have a dataset of sufficient size. An alternative is to pretrain a Conv-Net on a very large dataset (e.g. ImageNet), and then use the ConvNet either as an initialization or a fixed feature extractor for the task of interest. Typically, there are three major transfer learning scenarios: **ConvNet as fixed feature extractor:** We can take a ConvNet pretrained on ImageNet, and remove the last fully-connected layer, then treat the rest structure as a fixed feature extractor for the target dataset. In AlexNet, this would be a 4096-D vector. Usually, we call these features as CNN codes. Once we get these features, we can train a linear classifier (e.g. linear SVM or Softmax classifier) for our target dataset. **Fine-tuning the ConvNet:** Another idea is not only replace the last fully-connected layer in the classifier, but to also fine-tune the parameters of the pretrained network. Due to overfitting concerns, we can only fine-tune some higher-level part of the network. This suggestion is motivated by the observation that earlier features in a ConvNet contains more generic features (e.g. edge detectors or color blob detectors) that can be useful for many kind of tasks. But the later layer of the network becomes progressively more specific to the details of the classes contained in the original dataset. **Pretrained models:** The released pretrained model is usually the final ConvNet checkpoint. So it is common to see people use the network for fine-tuning. #### 4. 3D Autoencoder and Convolutional Neural Network We take a two-stage approach where we first train a 3D sparse autoencoder to learn filters for convolution operations, and then build a convolutional neural network whose first layer uses the filters learned with the autoencoder. ![] images/f2.png) #### 4.1. Sparse Autoencoder An autoencoder is a 3-layer neural network that is used to extract features from an input such as an image. Sparse representations can provide a simple interpretation of the input data in terms of a small number of \parts by extracting the structure hidden in the data. The autoencoder has an input layer, a hidden layer and an output layer, and the input and output layers have same number of units, while the hidden layer contains more units for a sparse and overcomplete representation. The encoder function maps input x to representation h, and the decoder function maps the representation h to the output x. In our problem, we extract 3D patches from scans as the input to the network. The decoder function aims to reconstruct the input form the hidden representation h. #### 4.2. 3D Convolutional Neural Network Training the 3D convolutional neural network(CNN) is the second stage. The CNN we use in this project has one convolutional layer, one pooling layer, two linear layers, and finally a log softmax layer. After training the sparse autoencoder, we take the weights and biases of the encoder from trained model, and use them a 3D filter of a 3D convolutional layer of the 1-layer convolutional neural network. Figure 2 shows the architecture of the network. #### 5. Tools In this project, we used Nibabel for MRI image processing and PyTorch Neural Networks implementation.
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            Community Discussions

            QUESTION

            Using RNN Trained Model without pytorch installed
            Asked 2022-Feb-28 at 20:17

            I have trained an RNN model with pytorch. I need to use the model for prediction in an environment where I'm unable to install pytorch because of some strange dependency issue with glibc. However, I can install numpy and scipy and other libraries. So, I want to use the trained model, with the network definition, without pytorch.

            I have the weights of the model as I save the model with its state dict and weights in the standard way, but I can also save it using just json/pickle files or similar.

            I also have the network definition, which depends on pytorch in a number of ways. This is my RNN network definition.

            ...

            ANSWER

            Answered 2022-Feb-17 at 10:47

            You should try to export the model using torch.onnx. The page gives you an example that you can start with.

            An alternative is to use TorchScript, but that requires torch libraries.

            Both of these can be run without python. You can load torchscript in a C++ application https://pytorch.org/tutorials/advanced/cpp_export.html

            ONNX is much more portable and you can use in languages such as C#, Java, or Javascript https://onnxruntime.ai/ (even on the browser)

            A running example

            Just modifying a little your example to go over the errors I found

            Notice that via tracing any if/elif/else, for, while will be unrolled

            Source https://stackoverflow.com/questions/71146140

            QUESTION

            Flux.jl : Customizing optimizer
            Asked 2022-Jan-25 at 07:58

            I'm trying to implement a gradient-free optimizer function to train convolutional neural networks with Julia using Flux.jl. The reference paper is this: https://arxiv.org/abs/2005.05955. This paper proposes RSO, a gradient-free optimization algorithm updates single weight at a time on a sampling bases. The pseudocode of this algorithm is depicted in the picture below.

            optimizer_pseudocode

            I'm using MNIST dataset.

            ...

            ANSWER

            Answered 2022-Jan-14 at 23:47

            Based on the paper you shared, it looks like you need to change the weight arrays per each output neuron per each layer. Unfortunately, this means that the implementation of your optimization routine is going to depend on the layer type, since an "output neuron" for a convolution layer is quite different than a fully-connected layer. In other words, just looping over Flux.params(model) is not going to be sufficient, since this is just a set of all the weight arrays in the model and each weight array is treated differently depending on which layer it comes from.

            Fortunately, Julia's multiple dispatch does make this easier to write if you use separate functions instead of a giant loop. I'll summarize the algorithm using the pseudo-code below:

            Source https://stackoverflow.com/questions/70641453

            QUESTION

            How can I check a confusion_matrix after fine-tuning with custom datasets?
            Asked 2021-Nov-24 at 13:26

            This question is the same with How can I check a confusion_matrix after fine-tuning with custom datasets?, on Data Science Stack Exchange.

            Background

            I would like to check a confusion_matrix, including precision, recall, and f1-score like below after fine-tuning with custom datasets.

            Fine tuning process and the task are Sequence Classification with IMDb Reviews on the Fine-tuning with custom datasets tutorial on Hugging face.

            After finishing the fine-tune with Trainer, how can I check a confusion_matrix in this case?

            An image of confusion_matrix, including precision, recall, and f1-score original site: just for example output image

            ...

            ANSWER

            Answered 2021-Nov-24 at 13:26

            What you could do in this situation is to iterate on the validation set(or on the test set for that matter) and manually create a list of y_true and y_pred.

            Source https://stackoverflow.com/questions/68691450

            QUESTION

            CUDA OOM - But the numbers don't add upp?
            Asked 2021-Nov-23 at 06:13

            I am trying to train a model using PyTorch. When beginning model training I get the following error message:

            RuntimeError: CUDA out of memory. Tried to allocate 5.37 GiB (GPU 0; 7.79 GiB total capacity; 742.54 MiB already allocated; 5.13 GiB free; 792.00 MiB reserved in total by PyTorch)

            I am wondering why this error is occurring. From the way I see it, I have 7.79 GiB total capacity. The numbers it is stating (742 MiB + 5.13 GiB + 792 MiB) do not add up to be greater than 7.79 GiB. When I check nvidia-smi I see these processes running

            ...

            ANSWER

            Answered 2021-Nov-23 at 06:13

            This is more of a comment, but worth pointing out.

            The reason in general is indeed what talonmies commented, but you are summing up the numbers incorrectly. Let's see what happens when tensors are moved to GPU (I tried this on my PC with RTX2060 with 5.8G usable GPU memory in total):

            Let's run the following python commands interactively:

            Source https://stackoverflow.com/questions/70074789

            QUESTION

            How to compare baseline and GridSearchCV results fair?
            Asked 2021-Nov-04 at 21:17

            I am a bit confusing with comparing best GridSearchCV model and baseline.
            For example, we have classification problem.
            As a baseline, we'll fit a model with default settings (let it be logistic regression):

            ...

            ANSWER

            Answered 2021-Nov-04 at 21:17

            No, they aren't comparable.

            Your baseline model used X_train to fit the model. Then you're using the fitted model to score the X_train sample. This is like cheating because the model is going to already perform the best since you're evaluating it based on data that it has already seen.

            The grid searched model is at a disadvantage because:

            1. It's working with less data since you have split the X_train sample.
            2. Compound that with the fact that it's getting trained with even less data due to the 5 folds (it's training with only 4/5 of X_val per fold).

            So your score for the grid search is going to be worse than your baseline.

            Now you might ask, "so what's the point of best_model.best_score_? Well, that score is used to compare all the models used when searching for the optimal hyperparameters in your search space, but in no way should be used to compare against a model that was trained outside of the grid search context.

            So how should one go about conducting a fair comparison?

            1. Split your training data for both models.

            Source https://stackoverflow.com/questions/69844028

            QUESTION

            Getting Error 524 while running jupyter lab in google cloud platform
            Asked 2021-Oct-15 at 02:14

            I am not able to access jupyter lab created on google cloud

            I created one notebook using Google AI platform. I was able to start it and work but suddenly it stopped and I am not able to start it now. I tried building and restarting the jupyterlab, but of no use. I have checked my disk usages as well, which is only 12%.

            I tried the diagnostic tool, which gave the following result:

            but didn't fix it.

            Thanks in advance.

            ...

            ANSWER

            Answered 2021-Aug-20 at 14:00

            QUESTION

            TypeError: brain.NeuralNetwork is not a constructor
            Asked 2021-Sep-29 at 22:47

            I am new to Machine Learning.

            Having followed the steps in this simple Maching Learning using the Brain.js library, it beats my understanding why I keep getting the error message below:

            I have double-checked my code multiple times. This is particularly frustrating as this is the very first exercise!

            Kindly point out what I am missing here!

            Find below my code:

            ...

            ANSWER

            Answered 2021-Sep-29 at 22:47

            Turns out its just documented incorrectly.

            In reality the export from brain.js is this:

            Source https://stackoverflow.com/questions/69348213

            QUESTION

            Ordinal Encoding or One-Hot-Encoding
            Asked 2021-Sep-04 at 06:43

            IF we are not sure about the nature of categorical features like whether they are nominal or ordinal, which encoding should we use? Ordinal-Encoding or One-Hot-Encoding? Is there a clearly defined rule on this topic?

            I see a lot of people using Ordinal-Encoding on Categorical Data that doesn't have a Direction. Suppose a frequency table:

            ...

            ANSWER

            Answered 2021-Sep-04 at 06:43

            You're right. Just one thing to consider for choosing OrdinalEncoder or OneHotEncoder is that does the order of data matter?

            Most ML algorithms will assume that two nearby values are more similar than two distant values. This may be fine in some cases e.g., for ordered categories such as:

            • quality = ["bad", "average", "good", "excellent"] or
            • shirt_size = ["large", "medium", "small"]

            but it is obviously not the case for the:

            • color = ["white","orange","black","green"]

            column (except for the cases you need to consider a spectrum, say from white to black. Note that in this case, white category should be encoded as 0 and black should be encoded as the highest number in your categories), or if you have some cases for example, say, categories 0 and 4 may be more similar than categories 0 and 1. To fix this issue, a common solution is to create one binary attribute per category (One-Hot encoding)

            Source https://stackoverflow.com/questions/69052776

            QUESTION

            How to increase dimension-vector size of BERT sentence-transformers embedding
            Asked 2021-Aug-15 at 13:35

            I am using sentence-transformers for semantic search but sometimes it does not understand the contextual meaning and returns wrong result eg. BERT problem with context/semantic search in italian language

            by default the vector side of embedding of the sentence is 78 columns, so how do I increase that dimension so that it can understand the contextual meaning in deep.

            code:

            ...

            ANSWER

            Answered 2021-Aug-10 at 07:39

            Increasing the dimension of a trained model is not possible (without many difficulties and re-training the model). The model you are using was pre-trained with dimension 768, i.e., all weight matrices of the model have a corresponding number of trained parameters. Increasing the dimensionality would mean adding parameters which however need to be learned.

            Also, the dimension of the model does not reflect the amount of semantic or context information in the sentence representation. The choice of the model dimension reflects more a trade-off between model capacity, the amount of training data, and reasonable inference speed.

            If the model that you are using does not provide representation that is semantically rich enough, you might want to search for better models, such as RoBERTa or T5.

            Source https://stackoverflow.com/questions/68686272

            QUESTION

            How to identify what features affect predictions result?
            Asked 2021-Aug-11 at 15:55

            I have a table with features that were used to build some model to predict whether user will buy a new insurance or not. In the same table I have probability of belonging to the class 1 (will buy) and class 0 (will not buy) predicted by this model. I don't know what kind of algorithm was used to build this model. I only have its predicted probabilities.

            Question: how to identify what features affect these prediction results? Do I need to build correlation matrix or conduct any tests?

            Table example:

            ...

            ANSWER

            Answered 2021-Aug-11 at 15:55

            You could build a model like this.

            x = features you have. y = true_lable

            from that you can extract features importance. also, if you want to go the extra mile,you can do Bootstrapping, so that the features importance would be more stable (statistical).

            Source https://stackoverflow.com/questions/68744565

            Community Discussions, Code Snippets contain sources that include Stack Exchange Network

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