mrgsolve | Simulate from ODE-based population PK/PD and QSP models in R

An adaptation to the email I sent my colleagues that were assisting me with a similar issue:

To review, I was unable to open any files through RStudio because RStudio returned error messages indicating either that the file itself or the work directory did not exist. I've done multiple installations of different versions of R, RStudio, and Rtools in an attempt to resolve the issue. I also moved the locations of files and programs of interest and changed the work directory to see if that made a difference. Unfortunately, when RStudio is first initiated on a computer, it establishes a "hidden directory" folder that retains the settings of the program when it was first initiated. However, by deleting this folder, RStudio was wiped and I was able to regain control of where files would be stored and read as desired (more on this in the following link: https://support.rstudio.com/hc/en-us/articles/200534577-Resetting-RStudio-Desktop-s-State). A combination of this and forcing Rtools to the front of the 'path' also allowed me to resolve 'status 127' errors that I was receiving as well.

Unfortunately, this is the result of a more personal issue between the initial settings that RStudio took to my computer and my attempt to manipulate where RStudio should read files which I guess were discordant of one another? Regardless, it seems that I would need to be more cognizant of how RStudio establishes a folder which retains its initial settings.