xtal-fetch | Vanilla-ish web component wrapper around the fetch method | HTTP library

To answer the question in the title: As long as the data binding is done within a Polymer host element, you could use Polymer data binding with native web components.

But it seems you're trying to use Polymer data binding inside the constructor of a native element (i.e., 's innerHTML uses Polymer data binding syntax). That won't work because you're not in a Polymer host element. If you convert to a Polymer element, you would then be able to use Polymer's data binding. If you otherwise prefer to use the native element, you'd have to manually setup the data binding in your element by adding an event listener on the result-changed event of .