MRO | The MHC Restriction Ontology | Genomics library

 by   IEDB Python Version: v2023-02-27 License: No License

kandi X-RAY | MRO Summary

kandi X-RAY | MRO Summary

MRO is a Python library typically used in Healthcare, Pharma, Life Sciences, Artificial Intelligence, Genomics applications. MRO has no bugs, it has no vulnerabilities, it has build file available and it has low support. You can download it from GitHub.

We recommend Protégé 5 beta for viewing MRO in OWL format. MHC molecules form a highly diverse family of proteins that play a key role in cellular immune recognition. Over time, different techniques and terminologies have been developed to identify the specific type(s) of MHC molecule involved in a specific immune recognition context. No consistent nomenclature exists across different vertebrate species. To correctly represent MHC related data in The Immune Epitope Database (IEDB), we built upon a previously established MHC ontology (MaHCO) and created MRO to represent MHC molecules as they relate to immunological experiments. MRO models MHC protein chains from 16 species, deals with different approaches used to identify MHC, such as direct sequencing verses serotyping, relates engineered MHC molecules to naturally occurring ones, connects genetic loci, alleles, protein chains and multichain proteins, and establishes evidence codes for MHC restriction. Where available, this work is based on existing ontologies from the OBO Foundry. We link to well-established MHC nomenclature resources of the international ImMunoGeneTics information system (IMGT) for human data and The Immuno Polymorphism Database (IPD) for non-human species. Vita et al., An Ontology for Major Histocompatibility Restriction, Journal of Biomedical Semantics, 2016.
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            kandi-support Support

              MRO has a low active ecosystem.
              It has 8 star(s) with 5 fork(s). There are 6 watchers for this library.
              OutlinedDot
              It had no major release in the last 12 months.
              There are 12 open issues and 15 have been closed. On average issues are closed in 284 days. There are 5 open pull requests and 0 closed requests.
              It has a neutral sentiment in the developer community.
              The latest version of MRO is v2023-02-27

            kandi-Quality Quality

              MRO has no bugs reported.

            kandi-Security Security

              MRO has no vulnerabilities reported, and its dependent libraries have no vulnerabilities reported.

            kandi-License License

              MRO does not have a standard license declared.
              Check the repository for any license declaration and review the terms closely.
              OutlinedDot
              Without a license, all rights are reserved, and you cannot use the library in your applications.

            kandi-Reuse Reuse

              MRO releases are available to install and integrate.
              Build file is available. You can build the component from source.
              Installation instructions, examples and code snippets are available.

            Top functions reviewed by kandi - BETA

            kandi has reviewed MRO and discovered the below as its top functions. This is intended to give you an instant insight into MRO implemented functionality, and help decide if they suit your requirements.
            • Validate a molecule tsv file
            • Check the fields of the reader
            • Convert a row and column index to A1
            • Render the site index
            • Update the molecules based on missing alleles
            • Create classII pair
            • Create MHC classII protein structure
            • Create a basic classII
            • Update the IEDB sheet with missing_molecules
            • Validate chain sequence
            • Render output
            • Read the rows from the given rows
            • Get the set of MHC class I and MHC classes
            • Create a message from errors
            • Return the taxon metadata for each species
            • Parse the fasta file and return a dictionary
            • Validate chain
            • Updates the index of the missing alleles
            • Validate serotype - molecule
            • Validate a mutant molecule
            • Validate the haplotype
            • Validate a haplotype molecule
            • Validate the genetic loci file
            • Update MHCFlurry alleles
            • Validate serotype labels
            • Updates the list of loci for each species
            Get all kandi verified functions for this library.

            MRO Key Features

            No Key Features are available at this moment for MRO.

            MRO Examples and Code Snippets

            MHC Restriction Ontology (MRO),Build Instructions,Testing
            Pythondot img1Lines of Code : 2dot img1no licencesLicense : No License
            copy iconCopy
            python3 -m pip install -r requirements.txt
            
            make test
              
            MHC Restriction Ontology (MRO),Build Instructions
            Pythondot img2Lines of Code : 1dot img2no licencesLicense : No License
            copy iconCopy
            make
              

            Community Discussions

            QUESTION

            "Cannot create a consistent method resolution order (MRO) for bases Widget, Screen" when using ScreenManager in kivy
            Asked 2021-Jun-05 at 08:39

            My code consists of 2 pages that each one has only a button by pressing which it's supposed to it to show the other page:

            ...

            ANSWER

            Answered 2021-Jun-04 at 14:59

            QUESTION

            Why is this inheritance structure built like this?
            Asked 2021-May-02 at 18:06

            I've been struggling to understand the details of this code for a couple of days now:

            ...

            ANSWER

            Answered 2021-May-02 at 18:06

            Good questions!

            1. Because Square.__init__ accepts **kwargs we can actually pass whatever we want to it without getting an unexpected keyword argument error1. This will become handy a bit later. Any keyword argument that it (and/or its superclasses' __init__ methods) does not consume will propagate up in the MRO until we get to object.


              1Usually. In this case the (unnecessery) call to

              super().__init__(**kwargs) in Triangle.__init__ breaks this behavior.


            1. Due to the expansion of kwargs, when calling super().__init__(base, **kwargs) in Pyramid.__init__, Square.__init__ is actually called with (2, height=3, length=2). Since the argument of Square.__init__ is called length you recieve the error about multiple values for length.

            2. That's correct. Furthermore, because nothing "consumed" the base keyword argument yet, Triangle.__init__ will receive it.

            3. That's also correct. There is absolutely no need to call super().__init__(**kwargs) in Triangle.__init__, especially that by that point kwargs is an empty dict (all the keyword arguments it contained were consumed already).

            Source https://stackoverflow.com/questions/67359334

            QUESTION

            Is there an NCO command to change the time stamp of a variable in a netcdf?
            Asked 2021-Apr-27 at 19:06

            I have a netcdf file containing maximum daily air temperature, time, lat and lon. I successfully got maximum temperature from a netcdf of 6 hourly temperatures using the nco command:

            ncra -y max --mro -d time,,,4,4 6hourly.nc max.nc"

            The only problem is, my time steps are still split into quarter days:

            variables:

            ...

            ANSWER

            Answered 2021-Feb-11 at 00:41

            ncap2 can work with attributes. However, you have a particularly thorny issue because your attribute name contains whitespace, and the attribute value is an array. I think in this case you need to first rename the attribute, then manipulate it. (Then you can rename it back if desired.):

            Source https://stackoverflow.com/questions/66068582

            QUESTION

            Why does the MRO of this class change when one subclass does/doesnt inherit a third class in Python?
            Asked 2021-Apr-27 at 13:31

            I'm trying to get a better understanding of MRO in Python & came across this example:

            ...

            ANSWER

            Answered 2021-Apr-27 at 13:31

            The C3 linearization algorithm is somewhat depth-first, so A, being reachable from B (which is listed before C in the base class list) is added before C.

            The rationale is that D is more "B-like" than "C-like", so anything that is part of "B" should appear before "C".

            (For fun, see what happens if you try something like class D(B, A, C) when C still inherits from A.)

            Source https://stackoverflow.com/questions/67283693

            QUESTION

            Python: can I use a class-level decorator to add a mixin to the decorated class?
            Asked 2021-Apr-15 at 17:28

            I'd like to have a decorator that, among other stuff, adds a mixin to the class it's decorating. (I recognize that this may be a Really Bad Idea but bear with me.) The following almost works:

            ...

            ANSWER

            Answered 2021-Apr-15 at 17:28

            Edit: The question was edited to mention this approach while I was writing the answer.

            You can do:

            Source https://stackoverflow.com/questions/67111644

            QUESTION

            Inheriting form two classes in python with super. can you call parent init methods with super()?
            Asked 2021-Apr-04 at 14:36

            Assuming this:

            ...

            ANSWER

            Answered 2021-Apr-03 at 14:26

            A child has a mother and a father and would best be designed to have mother and father attributes contained within. I think the following class definitions make more sense for your case:

            Source https://stackoverflow.com/questions/66931262

            QUESTION

            Copy folder structure but match subfolders based on the folder name in subdirectories by two different strings?
            Asked 2021-Mar-23 at 09:48

            How can one copy an entire folder structure but only select some folders several subdirectories down based on the folder name by two different strings ('Touch' or 'mpr') ?

            the files I need are in e.g.:

            ...

            ANSWER

            Answered 2021-Mar-21 at 22:20

            This is what I meant by string manipulation, try this and see if it works:

            Source https://stackoverflow.com/questions/66734764

            QUESTION

            Copy the entire folder structure but filter subfolders based on the folder name by two different strings?
            Asked 2021-Mar-21 at 12:30

            How can one copy the entire folder structure but only select some (sub-)folders based on the folder name by two different strings?

            I have tried

            ...

            ANSWER

            Answered 2021-Mar-21 at 12:30

            You are testing the name to be an exact match in the $includes array using the -in operator, but that array contains wildcard characters, so will not work.

            Instead, use the regex -match operator and set your $includes variable to be a string with partial names separated by the regex OR (|) character:

            Source https://stackoverflow.com/questions/66708164

            QUESTION

            Why does this parent class setter call use type(self) rather than self?
            Asked 2021-Mar-07 at 03:51

            Python @property inheritance the right way explains how to call the parent setter.

            ...

            ANSWER

            Answered 2021-Mar-07 at 03:51

            The problem with super(Integer, self).value.fset(self, _value) (or the simpler equivalent, super().value.fset(self, _value)) occurs before you even get to the fset. The descriptor protocol is engaged on all lookups on an instance, cause it to invoke the getter simply by doing super(Integer, self).value (or super().value). That's why your inherited getter works in the first place; it invoked the property descriptor, and got the value produced by it.

            In order to bypass the descriptor protocol (more precisely, move from instance to class level invocation, where propertys do nothing special in the class level scenario), you need to perform the lookup on the class itself, not an instance of it. super(Integer, type(self)) invokes the form of super that returns a super object bound at the class level, not the instance level, allowing you to retrieve the raw descriptor itself, rather than invoking the descriptor and getting the value it produces. Once you have the raw descriptor, you can access and invoke the fset function attached to it.

            This is the same issue you have when super isn't involved. If you have an instance of Number, and want to directly access the fset function (rather than invoking it implicitly via assignment), you have to do:

            Source https://stackoverflow.com/questions/66512930

            QUESTION

            Python - how to access instance properties in parent classes with super(, self)?
            Asked 2021-Feb-22 at 09:26

            Please explain why I cannot use super(class, self) to access the properties defined in the class higher in the class inheritance hierarchy, and how to access them.

            According to the document, super(class, self should be returning a proxy object via which I can access the def name() in a parent class instance.

            Return a proxy object that delegates method calls to a parent or sibling class of type. This is useful for accessing inherited methods that have been overridden in a class.

            The object-or-type determines the method resolution order to be searched. The search starts from the class right after the type.

            For example, if mro of object-or-type is D -> B -> C -> A -> object and the value of type is B, then super() searches C -> A -> object.

            I thought super(Parent) will give a proxy to the GrandParent object which has the def name().

            ...

            ANSWER

            Answered 2021-Feb-22 at 09:26

            The self always refers to one and the same object. When you do super().__init__(), the self in the parent's __init__ is your instance of Child. GrandParent.__init__ just sets an attribute on that object. By chaining all those __init__s, you're in effect just doing this:

            Source https://stackoverflow.com/questions/66312714

            Community Discussions, Code Snippets contain sources that include Stack Exchange Network

            Vulnerabilities

            No vulnerabilities reported

            Install MRO

            We use ROBOT and GNU Make to build MRO from template files, applying the Quick Term Template (QTT) approach (see Overcoming the ontology enrichment bottleneck with Quick Term Templates).
            core.tsv
            genetic-locus.tsv
            haplotype.tsv
            serotype.tsv
            chain.tsv
            molecule.tsv
            haplotype-molecule.tsv
            serotype-molecule.tsv
            mutant-molecule.tsv
            evidence.tsv
            chain-sequence.tsv
            import.txt lists the external ontology terms that we import
            external.tsv declares some external ontology terms

            Support

            For any new features, suggestions and bugs create an issue on GitHub. If you have any questions check and ask questions on community page Stack Overflow .
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