seqr | web-based analysis tool for rare disease genomics | Continuous Deployment library
kandi X-RAY | seqr Summary
kandi X-RAY | seqr Summary
seqr consists of the following components: - postgres - SQL database used by seqr to store project metadata and user-generated content such as variant notes, etc. - elasticsearch - NoSQL database used to store variant callsets. - redis - in-memory cache used to speed up request handling. - seqr - the main client-server application built using react.js, python and django. - pipeline-runner - optional container for running hail pipelines to annotate and load new datasets into elasticsearch. If seqr is hosted on google cloud (GKE or GCE), Dataproc spark clusters can be used instead. - kibana - optional dashboard and visual interface for elasticsearch.
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QUESTION
Good day!
I've just started playing around with pymongo
and multiprocessing. I have received a multicore unit for my experiments, which runs Ubuntu 18.04.4 LTS, codename: bionic
. Just for the sake of experiment I have tried it both with python 3.8
and python 3.10
, unfortunately the results are similar:
ANSWER
Answered 2021-Jul-01 at 17:45Each process needs to have its own client, therefore you most likely need to create the client in each process instead of creating one prior to invoking multiprocessing.
Forked process: Failure during socket delivery: Broken pipe contains general information on how MongoDB drivers handle forking.
QUESTION
I am going through the code of a project and I see the following code:
...ANSWER
Answered 2021-Apr-29 at 14:54url
is a local variable. Reassigning that variable, which is all this code is doing to it, has no possibility of affecting code outside of this function call. It doesn't make the function impure.
Now, if you were passed in an object, and you started mutating that object, then that would break purity. Because if the component that passed you this object is still using it, then it can "see" that change. For example:
QUESTION
I have such a _mapping
in Elasticsearch
6.8
:
ANSWER
Answered 2021-Feb-24 at 14:24_meta
is a reserved field for storing application-specific metadata. It's not meant to be searchable and can be only retrieved through the GET Mapping API.
This means that if your _meta
content was intended to be consistent with what the _meta
field is designed for, you cannot apply any mappings to it. It's a "final" hashmap of concrete values and would need to be defined at the top level of your update-mapping payload:
QUESTION
I am using redux-form
and at some point destroy
event is fired probably due to some state change, hard to say. I am using redux-dev-tools
and there, if I eliminate this event, it fixes the behavior of the form. If I look into trace
(redux-dev-tools
) section of the destroy
event it does not show any of my code, so I am having real trouble tracing it down. I am looking for either a way to trace down what is the root reason for the destroy
event in my code or just prevent all form updates after Submit
button is hit.
The actual issue is documented here: https://github.com/macarthur-lab/seqr/issues/1334
...ANSWER
Answered 2020-Jun-16 at 16:35From these 2 threads:
https://github.com/redux-form/redux-form/issues/2982
https://github.com/redux-form/redux-form/issues/603#issuecomment-295043224
I figured to supply destroyOnUnmount: false
property to my redux form
and it worked. To prevent saving form details when we go away from page and go back, I added enableReinitialize
parameter also.
QUESTION
I am running a spark job:
...ANSWER
Answered 2020-Feb-11 at 00:50Just posted the question and fixed it right away although was pretty desperate. The issue was that I was copy pasting the command in several editors and back and some wrong characters probably were present after --driver-memory 4g
. I just deleted spaces (that may not have been spaces) and reinserted them, and it started working. It shard to say why, maybe tab
or newline
messed it up somehow. I was using Microsoft One Note
- maybe it is doing some modifications of spaces...
QUESTION
I want to extract the single letter amino acid sequence of specific chains from a bunch of PDB files.
I'm able to do it using SeqIO.parse() but it feels quite unpythonic in my opinion:
...ANSWER
Answered 2020-Feb-10 at 10:38Expanding on @BioGeek answer, here is the equivalent code to extract the sequence when using PDBParser.get_structure() instead of SeqIO.parse()
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