lfc | R package for modelling count ratio data | Genomics library
kandi X-RAY | lfc Summary
kandi X-RAY | lfc Summary
Digital expression measurements (e.g. RNA-seq) are often used to determine the change of quantities upon some treatment or stimulus. The resulting value of interest is the fold change (often logarithmized). This effect size of the change is often treated as a value that can be computed as lfc(A,B) = log2 A/B. However, due to the probabilistic nature of the experiments, the effect size rather is a random variable that must be estimated. This fact becomes obvious when considering that A or B can be 0, even if the true abundance is non-zero. We have shown that this can be modelled in a Bayesian framework. The intuitively computed effect size is the maximum likelihood estimator of a binomial model, where the effect size is not represented as fold change, but as proportion (of note, the log fold change simply is the logit transformed proportion). The Bayesian prior corresponds to pseudocounts frequently used to prevent infinite fold changes by A or B being zero. Furthermore, the Bayesian framework offers more advanced estimators (e.g. interval estimators or the posterior mean, which is the optimal estimator in terms of squared errors). This R package offers the implementation to harness the power of this framework.
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QUESTION
I am newbie to both Entity Framework and Moq testing.
Below is my EF code:
ANSWER
Answered 2020-Dec-21 at 18:50Mocking db context is a bad idea - you can simply use an in memory context and avoid mocking everything. It will work just like the real database.
See these suggestions from Microsoft: https://docs.microsoft.com/en-us/ef/core/testing/
This question has some answers that show how to make the in memory context: Unit testing with EF Core and in memory database
QUESTION
I've got an issue that pertains to how to use jupyter widgets, dropdowns namely, to produce a workflow. Currently my intentions aren't working, and I am aiming to do the following:
- Run a function that produces a list
- This list is fed into a dropdown, from which I select one (x)
- x refers to another function, that has a dictionary, it picks up all values associated with this key, and produces another list
- The list is fed into another dropdown, from where I'd pick one value for processing.
Issue that I am coming up with, is that I can get the first list produced and fed into a dropdown. However the subsequent list is not captured, and rather the function is, which of course fails down the road. Let me illustrate with some code:
This bit of code simply goes through a list of dictionaries, and places all the unique league instances into a list:
...ANSWER
Answered 2020-Sep-30 at 09:01Ok so I actually managed to figure this out:
QUESTION
I have got two numeric dataframes, df1 with log fold changes (LFC) and df2 with p-values.
...ANSWER
Answered 2020-Jul-17 at 08:33One way is to paste the prefixes and Map, i.e.
QUESTION
I've got homework to do for my University. The task is to do 2 classes (Player and Team) where the first one creates 10 players with attributes and the second one groups 5 of them into one team and the other 5 into second team. Here are these classes.
...ANSWER
Answered 2020-Mar-28 at 14:40I think that the problem here is how you access the players.
In your code, you are copying the Players into their teams, and then modifying the Players that you copied in the class, thus not affecting the Players in the Team class itself.
In my opinion, you should access them through the instances of the Team class, like real_madrid.players[i].change_height(n). By doing so, you don't need anymore to explicitly instantiate the Player objects and then insert them in the Player vectors used to construct the Teams, but you could directly construct them in their respective vector, using emplace_back() (and thus avoiding useless copies).
QUESTION
I have controller like this:
...ANSWER
Answered 2020-Mar-04 at 23:55The list = lfc.getLeads(AccessToken.getToken()); will be called with each GET request. Either take a look at caching the responses which might be useful when you need to obtain a large volume of data often.
I'd start here: Baeldung's: Spring cache tutorial which gives you an idea about the caching. Then you can take a look at the EhCache implementation or implement own interceptor putting/getting from/to external storage such as Redis.
The caching is the only way I see to resolve this: Since the Feign client is called with a different request (based on the token) the data are not static and need to be cached.
QUESTION
I am currently seeing this error with my current setup.
Type '({ team: string | null; } | { team: string | null; } | { ...; } | { ...; } | { ...; } | Dispatch<...>)[]' is missing the following properties from type 'State': teamts(2739) index.d.ts(290, 9): The expected type comes from property 'value' which is declared here on type 'IntrinsicAttributes & ProviderProps'
My code is below, if any more detail is required let me know.
actions.ts
...ANSWER
Answered 2019-Dec-20 at 23:34If you want to pass the state and the dispatch through context you have to type it on the context, you can go with just this line but if you want type safety read further
QUESTION
I have a list of data that I am sending to google cloud. My current code looks like this:
...ANSWER
Answered 2019-Oct-21 at 19:09You can use async/await with a for...of loop. Each call will "hold" the loop, until it's done, and then the loop will continue the next call:
QUESTION
This is a straight up question, but in a switch statement is it ok not to return a default state?
The switch statement is in a React Component and looks like this.
...ANSWER
Answered 2019-Oct-11 at 08:09No, it's optional refer to switch on MDN:
defaultOptionalA default clause; if provided, this clause is executed if the value of expression doesn't match any of the case clauses.
Regardless, you should use a dictionary object instead of switch:
QUESTION
Still I am learning angular2. I am trying to learn how to send SOAP request to a web service, with a WSDL. I was searching for some examples and found one. I created a button and wanted to call that soap function to send request to server on a click. The project is successfully built but the function doesn't work.
...ANSWER
Answered 2018-Aug-08 at 12:14The errors don't show any SOAP related errors. All the errors tell that the property doesn't exist in the AppComponent.
Modify soap method code as below
QUESTION
I am trying to get a rule set working to allow users to see there own data...
My current rule set is:
...ANSWER
Answered 2019-May-13 at 07:52To allow users see trips added by them use the query-based rules like this;
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